differentia

DHARMA

Digital Human Avatar Reasoning and Modeling AI

From Data to Decision: AI Computational Foundation

Inputs

Multimodal Data

Integrates data points and knowledge from hundreds of millions of patients

  • Multi-omics & Literature
  • Real World Data
  • Pre-clinical and Clinical Trial
  • Proprietary Evidence
Mechanistic EngineMulti-layer Digital Twin Engine
Mechanistic digital twin engine with Virtual Patient Simulation, Drug Mechanism, Biological Mechanism and AI-Native Engine layers

Actionable

Decision Intelligence

R&D Decisions

  • Targets & Lead Prioritization
  • Trial Design Optimization
  • Segmentation

Capital Decisions

  • Asset Prioritization
  • Portfolio Optimization

Clinical Decisions

  • Precision Medicine

In Silico

AI Driven Virtual Experiments

Simulate perturbance & quantify results

EfficacySafety & ToxBiomarkersPoS Impact
Agentic AI core integrating multimodal life sciences data streams into reasoning, simulation and predictive insights
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AI Intelligence Layer

AI-powered mechanistic reasoning and virtual experimentation.

  • Learn

    Understand biology from multimodal data.

  • Reason

    Connect mechanisms, evidence, and hypotheses

  • Act & Simulate

    Deploy agents to orchestrate virtual experiments and decision workflows.

Connected biological mechanism network linking cells, signals and therapeutic response
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Biological Mechanism

Model disease as a connected human system. Multi-omics, literature and clinical evidence are integrated into reusable quantitative models linking cells, pathways, organs, biomarkers and disease endpoints.

Tumor-Immune interactions, immune escape and checkpoint dynamics

Self-antigen recognition, tolerance breakdown and cytokine cascades

Pathogen-host interactions, immune response dynamics and inflammatory cascades

Lipid synthesis and clearance, lipoprotein kinetics and metabolic homeostasis

Hepatocyte units, drug-metabolizing enzymes, liver injury and regeneration

Advancing the global frontier of multi-omics disease modeling

Integrated drug mechanism model connecting systemic exposure and receptor binding to intracellular signaling and target cell response

Drug Mechanism

Simulate how each therapy acts

Simulate how each therapy actually works in humans. Delivery, exposure, target engagement, pathway response, efficacy and safety—represented for every molecule and modality.

mAb and bispecific binding, target-mediated disposition, signaling and immune-effector effects.

Tumor penetration, target binding, linker deconjugation, payload release and intracellular handling.

Biodistribution, cellular uptake, transgene expression, durability and immune response.

Trafficking, expansion, persistence, tumor targeting and off-target risk.

Ligand–target affinity, target & non-target tissue uptake, radiation dose-toxicity risk.

Mechanistic interactions, scheduling and combined efficacy-safety outcomes.

Virtual patient simulation outputs for sensitivity analysis, model validation, treatment effects and plasma concentration profiles
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Virtual Patients & Trials Simulation

Simulate populations, not only an average patient.

Simulate heterogeneous populations — not the average patient. Calibrated virtual populations represent biological, pharmacological and clinical variability across thousands of scenarios.

  • Heterogeneity
  • Disease progression
  • Trial scenarios
  • Patient/Animal Reduction

  • Hundreds of Scenarios

    Simulated in hours, not months

  • Millions of Virtual Patients

    Fail in silico, succeed in reality

Why virtual trials

Human-relevant simulation where traditional models leave critical gaps

Virtual trials integrate multi-data for large-scale human systemic outcome simulation, recapitulating real human drug responses.

Disease Scope

differentiaAI + Digital Twin
Covers any disease & cross-indication mining
Organoid
Limited tissue types
Animal
Poor translation for complex human diseases

Throughput & Scale

differentiaAI + Digital Twin
Millions of virtual patients simulated in hours. One model supports full pipeline
Organoid
Slow culture cycles, not reusable
Animal
Long build cycles, limited sample size. Not reusable

Patient Heterogeneity

differentiaAI + Digital Twin
Infinite synthetic patient cohorts
Organoid
Single donor cell line focus
Animal
Inbred genetically uniform mice

Systemic Organ Dynamics

differentiaAI + Digital Twin
Whole-body systemic simulation (multi-organ)
Organoid
Single-tissue evaluation only
Animal
Systemic but non-human physiology

Human Relevance

differentiaAI + Digital Twin
High human biological fidelity (eliminates species gap)
Organoid
Missing dynamic systemic signaling
Animal
High failure rate due to species translation gap

Connect, do not disrupt

Add a live simulation layer to your existing R&D workflow —through custom built PaaS/IaaS or API integration

Connect data across projects and systems through custom developed PaaS/IaaS or APIs. Integrate new data and evidence, automatically update simulations and return decision-ready outputs, all in a secure environment.

Your data sources

Existing Systems & Data

Plug into what you already run

RWDLabsOmicsEDC
APIs

Differentia Digital Twin Trial™ Platform

Digital Twins Simulations

Map · Simulate · Review · Update

Mechanistic Digital TwinsReal-time Simulation
Decision Ready

Decision teams

Actionable Outputs

Real-Time Monitoring & supporting

AI-Native DashboardDynamic trial decision-makingScenario ComparisonRegulatory-Grade Report

Integrate: End-to-End R&D Decision Support

Can automate end-to-end simulation, integrate with existing tools and operations network.

Flexible Deployment: Cloud / Local / Server Solution

Dedicated environments — ensuring maximum data security and control.

AI-Native Platform as a Service (PaaS)

One-click, natural-language generation of dashboards, reports and evidence packages.