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Building pharma's first industrial-grade digital twin engineWhere failures end in silico, success begins in reality.

Digital Twins
AI × Mechanistic Models
Virtual Clinical Trials
New Paradigm for Drug Development

Drug Development Pipeline

End-to-end modeling support

01

Discovery & Optimization

Preclinical

  • Target identification and validation
  • Model-supported lead optimization and candidate selection
  • Best-in-class property identification and competitive benchmarking
02

Preclinical to Clinical

Translational

  • Model-based characterization of therapeutic index
  • Human efficacious dose and safe starting dose prediction
  • Design of preclinical and phase I studies
03

Phase I-III Trials

Clinical

  • Population PK/PD analysis
  • Selection of RP2D and design of clinical phase II/III trials
  • Patient stratification and biomarker selection

Scientific Disciplines

Core areas of expertise

Clinical Pharmacology
01

Clinical Pharmacology

Support for Phases I, II, and III clinical trials for First-in-Human Dose (FHD), Single Ascending Dose (SAD), Multiple Ascending Dose (MAD), Drug-Drug Interaction (DDI), Bioavailability/Bioequivalence (BA/BE), and Food Effect.

Design dose selection strategy
ADME studies
PK analysis, interpretation and reporting
Provide initial concepts through New Drug Application (NDA)
Assistance with regulatory compliance
Assess market/clinical needs
Pharmacometrics
02

Pharmacometrics

Enhance drug development success with quantification of exposure-response to optimize clinical trials in time and resources, by preventing adverse events and providing the right dose to the right patient.

Non compartmental analysis (NCA)
Pharmacokinetic (PK) models
Pharmacodynamic (PD) models
PK/PD models
Optimal design
Longitudinal disease modeling
Paediatric expertise
03

Paediatric expertise

We are experienced in providing full service consultative service crossing the research continuum in the following main areas.

Aid in paediatric drug development (PSP or PIP)
Focus on special populations
Maternal and Child Health
Human growth and development
Newborn and Neonatal Individuals
Pediatrics
Chronic medical conditions arising in childhood

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