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Senior Scientist, Mechanistic Modeling

Job Summary 

As the Senior Scientist Pharmacometrics, you will contribute to our Pharmacometrics Business Unit in areas including pharmacokinetic/pharmacodynamic (PK/PD) modeling, PopPK (Population Pharmacokinetics), exposure-response analysis, strategic study design, dose selection, regulatory submissions, and advanced simulations.  

Location: Sydney, Australia.  


Key Responsibilities 

  • Develop Pharmacometrics models and simulations, optimizing study designs and informing key decision points. 
  • Develop PK/PD models, PopPK, Exposure Response Analysis, Study Design, Dose Selection, and contribute to Regulatory Submissions.  
  • Generate Model-based insights for patient segmentation and biomarker identification. 
  • Collaborate closely with cross-functional teams and external partners, aligning pharmacometrics strategies with overall drug development plans. 
  • Stay current with advancements in pharmacometrics, clinical pharmacology, and regulatory guidelines, integrating innovative methodologies into our approach. 
  • Attend conferences, collaborate with external partners, and contribute to scientific publications. 



  • Ph.D. or equivalent in Clinical Pharmacology, Pharmacometrics, or related field. 
  • Experience in Pharmacometrics including PK/PD modeling, Population PK, Exposure Response Analysis, Dose Selection within the biopharmaceutical industry. 
  • Expertise in applying modeling and simulation to support drug development programs, specifically for early-phase clinical trials. 


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